Dose-response analysis in the joint action of two effectors. A new approach to simulation, identification and modelling of some basic interactions.
In systems with several effectors, the results of dose-response (DR) experiments are usually Champagne Flutes assessed by checking them against two hypotheses: independent action (IA) and concentration addition (CA).Both are useful simplifications, but do not represent the only possible responses, and avoid to a large extent the analysis of the int